Tumor-associated B-cells induce tumor heterogeneity and therapy resistance
نویسندگان
چکیده
منابع مشابه
Tumor Heterogeneity and Drug Resistance
Title of dissertation: MATHEMATICAL MODELS OF TUMOR HETEROGENEITY AND DRUG RESISTANCE James Greene, Doctor of Philosophy, 2015 Dissertation directed by: Professor Doron Levy Department of Mathematics In this dissertation we develop mathematical models of tumor heterogeneity and drug resistance in cancer chemotherapy. Resistance to chemotherapy is one of the major causes of the failure of cancer...
متن کاملTumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice.
Cancer immunotherapeutic approaches induce tumor-specific immune responses, in particular CTL responses, in many patients treated. However, such approaches are clinically beneficial to only a few patients. We set out to investigate one possible explanation for the failure of CTLs to eliminate tumors, specifically, the concept that this failure is not dependent on inhibition of T cell function. ...
متن کاملCD40-activated B cells induce anti-tumor immunity in vivo
The introduction of checkpoint inhibitors represents a major advance in cancer immunotherapy. Some studies on checkpoint inhibition demonstrate that combinatorial immunotherapies with secondary drivers of anti-tumor immunity provide beneficial effects for patients that do not show a strong endogenous immune response. CD40-activated B cells (CD40B cells) are potent antigen presenting cells by ac...
متن کاملHuman Cancer Modeling: Recapitulating Tumor Heterogeneity Towards Personalized Medicine
Despite diagnostic, preventive and therapeutic advances, growing incidence of cancer and high rate of mortality among patients affected by specific cancer types indicate current clinical measures are not ideally useful in eradicating cancer. Chemoresistance and subsequent disease relapse are believed to be mainly driven by the cell-molecular heterogeneity of human tumors that necessitates perso...
متن کاملHuman Cancer Modeling: Recapitulating Tumor Heterogeneity Towards Personalized Medicine
Despite diagnostic, preventive and therapeutic advances, growing incidence of cancer and high rate of mortality among patients affected by specific cancer types indicate current clinical measures are not ideally useful in eradicating cancer. Chemoresistance and subsequent disease relapse are believed to be mainly driven by the cell-molecular heterogeneity of human tumors that necessitates perso...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2017
ISSN: 2041-1723
DOI: 10.1038/s41467-017-00452-4